Reactivation and infection from cytomegalovirus in patients undergoing high-dose chemotherapy and autologous stem cell transplantation
Georgiadi Elpida, Polikandrioti Maria, Mpaseta Angeliki, Alexopoulou Nektaria, Gourni Maritsa
Sunday, September 1, 2013
- Georgiadi Elpida, RN, MSc, Associate Head of Thalassemia Unit, General Hospital of Athens "Laiko"
- Polikandrioti Maria, Assistant Professor,Department of Nursing,Technological Educational Institute of Athens
- Mpaseta Angeliki, Head Nurse of Clinical Pathology in General Hospital of Athens "Laiko"
- Alexopoulou Nektaria, RN, MSC, Unit of Treatment with Pharmaceutical Substitutes, OKANA Hospital “Agioi Anargyroi”
- Gourni Maritsa, Professor of Nursing
Purpose : The purpose of the present research was to record the frequency of CMV presence among patients undergoing autologous blood stem cell transplantation.
Material and Method: The study population consisted of 95 patients, hospitalized at the Bone Marrow Transplantation Unit of a public General Hospital of Athens. Data were collected by a specially designed questionnaire for the needs of the present research. For statistical analysis was used SPSS 13.0 statistic programme and the statistical methods used were Mann-Whitney, t-test, Kruskal-Willis test, Kolmogorov-Smirnov test for checking the normality of the distribution. The measure of the correlation between variables was the Pearson product-moment correlation coefficient (typically denoted by r). The significance levels are bilateral and the statistical significance is placed at 0.05.
Results: In this study of patients who underwent autologous transplantation, only 7 out of 84 patients (21,2%) had CMV reactivation and infection. The reactivation of the virus took place within 1 – 3 years after the transplantation. The analysis showed that none of these patients died of infection related to the virus.