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THE ROLE OF ANTIMICROBIAL PROPHYLAXIS IN THE PREVENTION OF SURGICAL SITE INFECTIONS - SYSTEMATIC REVIEW

Mpesikos Panagiotis, Vasilopoulos Georgios, Koutelekos John, Avramopoulou Lamprini, Charcharidou Maria

Friday, January 1, 2021

Publication Year:

2021

Authors:

Keywords Index:

Pages: 28-50

DOI: 10.5281/zenodo.5501820

Abstract:

Introduction: Surgical Site Infections (SSIs) and their prevention are the subject of research and study by the global scientific community. According to the ECDC, SSIs are the third most common cause of nosocomial infections.Objective: The purpose of this systematic review was to investigate the role and utility of antimicrobial prophylaxis (AMP) in the prevention of surgical site infections (SSIs).Material and methods: The search concerned studies (randomized controlled studies and cohort study) published in Greek and English in the decade 2009- 2018.Twenty (20) of these published studies, met the inclusion criteria and concerned the comparison of antibiotics as antimicrobial prophylaxis(AMP) in the prevention of SSIs, the investigation of the correct timing of the antimicrobial prophylaxis and, more generally, the importance of its role as a means of preventing SSIs. Results: The use of AMP may vary depending on the type of surgery. The administration of AMP should be done 15 to 60 min. prior to surgery depending on the antibiotic agent. Incorrect use of antibiotics leads to an increase in the incidence of SSIs. Administration of an additional dose of AMP in long-term surgery. Antimicrobial prophylaxis plays an important role in this direction when administered at the right time and the appropriate antimicrobial agents are used depending on the procedure. Unnecessary use of antibiotics should be avoided so as not to create multidrug resistant microbial strains such as MRSA. Conclusion: Prevention of surgical site infections significantly reduces both the cost of hospitalization and morbidity and mortality rates. Need to further investigate the role of antimicrobial prophylaxis through newer studies.

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